1248913-50mg 1248913-10mg
Wnt-C59
Biogems
DESCRIPTION
Wnt-C59 is a highly potent Porcupine (PORCN) inhibitor that prevents Wnt-3a palmitoylation, secretion and activation (IC50=74pM). It is reported to inhibit cancer cell proliferation in cancer cell lines depended on Wnt activity. Together with CHIR 99021, Wnt-C59 can be used to induce cardiomyocyte differentiation from human induced pluripotent stem cells (iPSCs).
DETAILS
- Purity: ≥98%
- Synonyms: WNTC59
- Cas Number: 1243243-89-1
- References: Cheng, Y., Phoon, Y. P., Jin, X., Chong, S. Y. S., Ip, J. C. Y., Wong, B. W. Y., & Lung, M. L. (2015). Wnt-C59 arrests stemness and suppresses growth of nasopharyngeal carcinoma in mice by inhibiting the Wnt pathway in the tumor microenvironment. Oncotarget, 6(16), 14428. Proffitt, K. D., Madan, B., Ke, Z., Pendharkar, V., Ding, L., Lee, M. A., ... & Virshup, D. M. (2013). Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer. Cancer research, 73(2), 502-507. Kadari, A., Mekala, S., Wagner, N., Malan, D., Köth, J., Doll, K., ... & Sasse, P. (2015). Robust generation of cardiomyocytes from human iPS cells requires precise modulation of BMP and WNT signaling. Stem Cell Reviews and Reports, 11(4), 560-569.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: 2-[4-(2-methylpyridin-4-yl)phenyl]-N-(4-pyridin-3-ylphenyl)acetamide
- Molecular Weight: 379.5
- Molecular Formula: C25H21N3O
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CC1=NC=CC(=C1)C2=CC=C(C=C2)CC(=O)NC3=CC=C(C=C3)C4=CN=CC=C4