TMPH-02687
Granzyme A/GZMA Protein, Mouse, Recombinant (His)
TargetMol
DESCRIPTION
Abundant protease in the cytosolic granules of cytotoxic T-cells and NK-cells which activates caspase-independent pyroptosis when delivered into the target cell through the immunological synapse. It cleaves after Lys or Arg. Cleaves APEX1 after 'Lys-31' and destroys its oxidative repair activity. Cleaves the nucleosome assembly protein SET after 'Lys-189', which disrupts its nucleosome assembly activity and allows the SET complex to translocate into the nucleus to nick and degrade the DNA.
DETAILS
- Purity: 98%
- Category: Compound
- Molecular Weight: 31.6 kDa as predicted
Lead Time: 4 - 5 weeks
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