BP6329c
hCLC1-G972 Blocking Peptide
Abcepta
DETAILS
- Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
- Gene Id: 1180
- Category: Peptides; Blocking Peptides
- Subtitle: Synthetic peptide
- Gene Name: CLCN1
- Other Names: Chloride channel protein 1, ClC-1, Chloride channel protein, skeletal muscle, CLCN1, CLC1
- Availability: 2 weeks
- Bio Background: The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. The protein encoded by this gene regulates the electric excitability of the skeletal muscle membrane. Mutations in this gene cause two forms of inherited human muscle disorders: recessive generalized myotonia congenita (Becker) and dominant myotonia (Thomsen).
- Bio References: Jou, S.B., et al., J. Neurol. 251(6):666-670 (2004). Hebeisen, S., et al., J. Biol. Chem. 279(13):13140-13147 (2004). Letizia, C., et al., Calcif. Tissue Int. 74(1):42-46 (2004). Estevez, R., et al., Neuron 38(1):47-59 (2003). Pusch, M., Hum. Mutat. 19(4):423-434 (2002).
- Other Accession: P35524; Q64347
- Primary Accession: P35523
- Targetspecificity: The synthetic peptide sequence is selected from aa 972~988 of HUMAN CLCN1