Monoclonal Antibody to GRP94 / HSP90B1 (Endoplasmic Reticulum Marker)(Clone : HSP90B1/1192)

DESCRIPTION

Recognizes a protein of 94kDa, which is identified as the glucose-regulated protein 94 (grp94) and also tumor rejection antigen (gp96). Grp94 shows a high degree of sequence homology with the heat shock protein 90 (hsp90). This MAb is highly specific to grp94 and shows minimal cross-reaction with other members of the HSP90 family. Grp s are a class of proteins unresponsive to heat shock and are induced by glucose deprivation. Grp94 has been briefly studied as a prognostic factor in breast cancer.

DETAILS

Gene: HSP90B1
App Id: IHC
Antigen: GRP94 / HSP90B1 (Endoplasmic Reticulum Marker)
Gene Id: 7184
Isotype: Rat IgG2a, kappa
Format Id: Purified
Clone Name: HSP90B1/1192
Uniprot Id: P14625
Host Animal: Rat
Clonality Id: Monoclonal
Purification: Affinity Chromatography
Reactivity Id: Human
Product Content: 100 µg in 500 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Alternative Name: HSP90B1||GRP94||TRA1
Application Note: Immunohistochemistry (Formalin-fixed) (1-2ug/ml for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes);
Categories Name 1: Antibodies
Categories Name 2: Cancer Marker
Storage Condition: Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Recombinant full-length human HSP90B1 protein