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300-36A

Recombinant Human MDC (CCL22) (69 a.a.)

PeproTech

DETAILS

  • Gene Id: 6367
  • Uniprot: O00626
  • Activity: Determined by its ability to chemoattract human T cells using a concentration range of 10.0-100.0 ng/ml.
  • Category: RUO Cytokines
  • Subcategory: Chemokines
  • Research Areas: AIDS/HIV, Chemotaxis, Immune System, Wound Healing
  • Alternative Names: Macrophage-Derived Chemokine, CCL22, STCP-1, ABCD-1
  • Species of Origin: Human
  • Expression System Source: E.coli

DESCRIPTION

MDC is a CC chemokine that is produced in B cells, macrophages, monocyte-derived dendritic cells, activated NK cells and CD4 T cells. It signals through the CCR4 receptor. MDC chemoattracts monocytes, dendritic cells and NK cells, and exerts HIV-suppressive activity. The 67 amino acid form of MDC displays reduced chemoattractant activity, but retains HIV-suppressive activity. Recombinant Human MDC is an 8.1 kDa protein containing 69 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.