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Lovastatin
Biogems
DESCRIPTION
Lovastatin is potent inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase) that was initially isolated from A. terreus. It interferes with the production of cholesterol and suppresses TNF-induced NF-kB activation.
DETAILS
- Purity: ≥98%
- Synonyms: Mevacor, Mevinolin, 6-Methylcompactin, MK-803
- Cas Number: 75330-75-5
- References: Alberts, A. W. (1988). Discovery, biochemistry and biology of lovastatin. The American journal of cardiology, 62(15), J10-J15. Jakobisiak, M., Bruno, S., Skierski, J. S., & Darzynkiewicz, Z. (1991). Cell cycle-specific effects of lovastatin. Proceedings of the National Academy of Sciences, 88(9), 3628-3632. Feleszko, W., Bałkowiec, E. Z., Sieberth, E., Marczak, M., Dabrowska, A., Giermasz, A., ... & Jakóbisiak, M. (1999). Lovastatin and tumor necrosis factor‐α exhibit potentiated antitumor effects against Ha‐ras‐transformed murine tumor Via inhibition of tumor‐induced angiogenesis. International journal of cancer, 81(4), 560-567.
- Application: FA
- Formulation: Crystalline solid
- Chemical Name: [(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
- Molecular Weight: 404.5
- Molecular Formula: C24H36O5
- Storage Conditions: Product should be kept at -20°C.
- Pubchem Openeye Can Smiles: CCC(C)C(=O)OC1CC(C=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O)C