PCDHA8 Antibody (C-term) Blocking peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 56140
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: PCDHA8
Other Names: Protocadherin alpha-8, PCDH-alpha-8, PCDHA8
Availability: 2 weeks
Bio Background: This gene is a member of the protocadherin alpha genecluster, one of three related gene clusters tandemly linked onchromosome five that demonstrate an unusual genomic organizationsimilar to that of B-cell and T-cell receptor gene clusters. Thealpha gene cluster is composed of 15 cadherin superfamily genesrelated to the mouse CNR genes and consists of 13 highly similarand 2 more distantly related coding sequences. The tandem array of15 N-terminal exons, or variable exons, are followed by downstreamC-terminal exons, or constant exons, which are shared by all genesin the cluster. The large, uninterrupted N-terminal exons eachencode six cadherin ectodomains while the C-terminal exons encodethe cytoplasmic domain. These neural cadherin-like cell adhesionproteins are integral plasma membrane proteins that most likelyplay a critical role in the establishment and function of specificcell-cell connections in the brain. Alternative splicing has beenobserved and additional variants have been suggested but theirfull-length nature has yet to be determined.
Bio References: Wu, C., et al. Proteomics 7(11):1775-1785(2007)Wu, Q., et al. Genome Res. 11(3):389-404(2001)Nollet, F., et al. J. Mol. Biol. 299(3):551-572(2000)Yagi, T., et al. Genes Dev. 14(10):1169-1180(2000)Wu, Q., et al. Proc. Natl. Acad. Sci. U.S.A. 97(7):3124-3129(2000)
Primary Accession: Q9Y5H6