mouse monoclonal IgG1; UGT1A6 Antibody (C-12) is an IgG1 κ mouse monoclonal UGT1A6 antibody (also designated UDPGT antibody, GNT1 antibody, UGT1 antibody, UGT1F antibody, UGT1.6 antibody or UDP-glucuronosyltransferase 6 antibody) that detects the UGT1A6 protein of human origin by WB, IP, IF and ELISA. UGT1A6 Antibody (C-12) is available as both the non-conjugated anti-UGT1A6 antibody form, as well as multiple conjugated forms of anti-UGT1A6 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Glucuronidation, an important bile acid detoxification pathway, is catalyzed by enzymes belonging to the UDP-glucuronosyltransferase (UGT) superfamily. UGT genes are classified into the UGT1A and UGT2B subfamilies. Although each subfamily and each isoform shows tissue-specific patterns of distribution, the underlying mechanisms for this tissue specificity have not been fully elucidated. The human UDP-glucuronosyltransferase 1 (UGT1) locus encodes at least ten UGT1A proteins (UGT1A1-UGT1A10) that play a prominent role in drug and xenobiotic metabolism. Research indicates that nuclear receptors such as pregnane X receptor (PXR), constitutive androstane receptor (CAR) and peroxisome proliferator-activated receptor (PPAR) can regulate UGTs, which may contribute to the tissue-specific expression pattern of UGTs. Deficiency in the expression and/or activity of UGTs may lead to genetic and acquired diseases such as Crigler-Najjar syndrome and Gilbert syndrome. Based on their ability to catalyze the glucuronidation of xenobiotics and endobiotics, UGTs play a critical role in hormonal homeostasis, energy metabolism, bilirubin clearance and xenobiotic detoxification.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.