10-1051-25 10-1051
Monoclonal Antibody to Cytochrome C (Clone: ABM30D4)
Abeomics
DESCRIPTION
Cytochrome C is an inner mitochondrial membrane hemeprotein encoded by CYCS gene. Cytochrome C has two major roles within the cell; firstly, it acts as an electron carrier between Complex III (Cytochrome bc1 complex) and Complex IV (Cytochrome C oxidase). The second important function of Cytochrome C is in apoptosis. In response to extrinsic or intrinsic signals and upon suppression of anti-apoptotic molecules, several pro-apoptotic molecules are activated that disturb the mitochondrial membrane permeability and causes the release of Cytochrome C. Cytochrome C then binds to apoptotic protease activating factor-1 (Apaf-1). This complex interacts with pro-caspase 9 and initiates the caspase cascade resulting in apoptosis. Human Cytochrome C has a molecular mass of 11 kDa. Defect in the CYCS gene is associated with autosomal dominant diseases like thrombocytopenia type 4 (THC4). High levels of Cytochrome C are found in blood leukocytes, kidney, liver, heart and brain.
DETAILS
- Gene: CYCS
- App Id: WB
- Antigen: Cytochrome C
- Gene Id: 54205
- Isotype: Mouse IgG1 Kappa
- Format Id: Purified
- Clone Name: ABM30D4
- Uniprot Id: P99999
- Host Animal: Mouse
- Clonality Id: Monoclonal
- Purification: Protein G Chromatography
- Reactivity Id: Rat,Mouse,Human
- Product Content: 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
- Alternative Name: CYCS||CYC
- Application Note: Western blot analysis: 2-4 µg/ml
- Storage Condition: Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
- Immunogen Information: Full length recombinant Cytochrome C protein was used as the immunogen for this antibody.
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