MBP Blocking Peptide (Y203)

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 4155
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: MBP
Other Names: Myelin basic protein, MBP, Myelin A1 protein, Myelin membrane encephalitogenic protein, MBP
Availability: 2 weeks
Bio Background: MBP is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, MBP-related transcripts are also present in the bone marrow and the immune system. These mRNAs arise from the long MBP gene (otherwise called Golli-MBP) that contains 3 additional exons located upstream of the classic MBP exons. Alternative splicing from the Golli and the MBP transcription start sites gives rise to 2 sets of MBP-related transcripts and gene products. The Golli mRNAs contain 3 exons unique to Golli-MBP, spliced in-frame to 1 or more MBP exons. They encode hybrid proteins that have N-terminal Golli aa sequence linked to MBP aa sequence. The second family of transcripts contain only MBP exons and produce the well characterized myelin basic proteins. This complex gene structure is conserved among species suggesting that the MBP transcription unit is an integral part of the Golli transcription unit and that this arrangement is important for the function and/or regulation of these genes.
Bio References: Kawamura,K., J. Immunol. 181 (5), 3202-3211 (2008) Majava,V., BMC Struct. Biol. 8, 10 (2008) Boylan,K.B.,Genomics 6 (1), 16-22 (1990)
Primary Accession: P02686
Targetspecificity: The synthetic peptide sequence is selected from aa 192-209 of HUMAN MBP