Skip to Main Content
Welcome to the Scientist.com Marketplace

Go to Main Navigation

B2693-077119

Gap 26

BOC Sciences

Thumbnail image

DETAILS

  • Iupac: (2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-amino-3-methylbutanoyl]amino]-3-sulfanylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-carboxypropanoyl]amino]hexanoyl]amino]-3-hydroxypropanoyl]amino]-3-phenylpropanoyl]pyrrolidine-2-carbonyl]amino]-3-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-methylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoic acid
  • Smiles: CCC(C)C(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(C(C)C)C(=O)NC(CCCN=C(N)N)C(=O)O)NC(=O)C2CCCN2C(=O)C(CC3=CC=CC=C3)NC(=O)C(CO)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(CC4=CC=C(C=C4)O)NC(=O)C(CS)NC(=O)C(C(C)C)N
  • Aliases: H-Val-Cys-Tyr-Asp-Lys-Ser-Phe-Pro-Ile-Ser-His-Val-Arg-OH; L-valyl-L-cysteinyl-L-tyrosyl-L-alpha-aspartyl-L-lysyl-L-seryl-L-phenylalanyl-L-prolyl-L-isoleucyl-L-seryl-L-histidyl-L-valyl-L-arginine; Gap26; Gap-26; Connexin 43 (63-75) (human, bovine, mouse, rat); Gap Junction α-1 Protein (63-75)
  • Cas Number: 197250-15-0
  • Molecular Weight: 1550.78
  • Molecular Formula: C70H107N19O19S

DESCRIPTION

Gap 26 is a gap junction blocker which is corresponding to residues 63 - 75 of connexin 43. Gap 26 was shown to attenuate rhythmic contractile activity of rabbit arterial smooth muscle (IC50 = 28.4 μM). It also inhibits IP3-induced ATP release but does not inhibit gap junctional coupling in endothelial cells.