MCAM Antibody (Y641) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 4162
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: MCAM
Other Names: Cell surface glycoprotein MUC18, Cell surface glycoprotein P1H12, Melanoma cell adhesion molecule, Melanoma-associated antigen A32, Melanoma-associated antigen MUC18, S-endo 1 endothelial-associated antigen, CD146, MCAM, MUC18
Availability: 2 weeks
Bio Background: MCAM plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. It could be an adhesion molecule active in neural crest cells during embryonic development. It acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2, and a transient increase in the intracellular calcium concentration.
Bio References: Fritzsche,F.R., Pathology 40 (5), 457-464 (2008)Malyszko,J., Clin. Appl. Thromb. Hemost. 14 (3), 338-345 (2008)Guezguez,B., J. Immunol. 179 (10), 6673-6685 (2007)
Other Accession: NP_006491
Primary Accession: P43121
Targetspecificity: The synthetic peptide sequence used to generate the antibody AP2767a was selected from the Y641 region of human MCAM. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.