Monoclonal Antibody to Mouse PD-L1 (Clone: 10F.9G2)

DESCRIPTION

PD-L1 (CD274/B7-H1) is a critical membrane-bound costimulatory molecule belonging to the B7 superfamily that inhibits immune responses through its receptor, PD-1. PD-L1 plays a key role in the pathogenesis of inflammatory diseases (programmed death 1). It is widely expressed in the mononuclear phagocyte system (MPS), may co-stimulate T cells, and regulates inflammatory responses. PD-L1 exerts inflammation regulatory functions via a negative co-stimulatory effect on T cell functions to inhibit cytokine secretion, facilitate apoptosis of activated T cells and induce T cell anergy. Aberrant expression and dysregulation of CD274/PD-L1 have been reported during bacterial infection, inflammation, and in numerous autoimmune diseases.

DETAILS

Gene: Cd274
App Id: FACS
Antigen: Programmed cell death 1 ligand 1
Gene Id: 60533
Isotype: Rat IgG2b, k
Format Id: Purified
Clone Name: 10F.9G2
Uniprot Id: Q9EP73
Host Animal: Rat
Clonality Id: Monoclonal
Purification: Protein G Chromatography
Reactivity Id: Mouse
Product Content: 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Alternative Name: Programmed cell death 1 ligand 1, Programmed cell death 1 ligand 1, Programmed death ligand 1, B7-H1
Application Note: Flowcytometric Analysis: 0.2-0.4 µg/10^6 Cells
Storage Condition: Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.
Immunogen Information: Mouse CD274