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B0084-482218

Scientist.com Supplier

Plecanatide

BOC Sciences

- Open Babel Depiction CH 3 NH 2 O N H H 3 C CH 3 O NH O O NH S S O NH 2 HO O N H O N H O OH H 3 C NH 2 N H O O HN H 3 C CH 3 O N H HN O N H H 3 C H 3 C O S S O N H H 3 C O O N H OH O O N H HO CH 3 O HN O N H HO O

DESCRIPTION

Plecanatide, also called Trulance, a synthetic analogue of uroguanylin, is a guanylate cyclase-C (GCC) agonist being developed by Synergy Pharmaceuticals for the treatment of gastrointestinal disorders, such as chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). In January 2017, an oral formulation of plecanatide received its first global approval in the USA for the treatment of adult patients with CIC. Besides, Plecanatide is undergoing phase III investigation in IBS-C. It had also undergone preclinical investigations in inflammatory bowel disease (IBD) and ulcerative colitis; however, development in these indications has been discontinued.

DETAILS

  • Iupac: (2S)-2-[[(1R,4S,7S,10S,13S,16R,19S,22S,25R,32S,38R)-10-(2-amino-2-oxoethyl)-25-[[(2S)-4-carboxy-2-[[(2S)-3-carboxy-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]amino]butanoyl]amino]-22-(2-carboxyethyl)-32-[(1R)-1-hydroxyethyl]-4-methyl-19-(2-methylpropyl)-3,6,9,12,15,18,21,24,30,33,36-undecaoxo-7,13-di(propan-2-yl)-27,28,40,41-tetrathia-2,5,8,11,14,17,20,23,31,34,37-undecazabicyclo[14.13.13]dotetracontane-38-carbonyl]amino]-4-methylpentanoic acid
  • Smiles: CC1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)CNC(=O)C(NC2=O)C(C)O)C(=O)NC(CC(C)C)C(=O)O)C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1)C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(CC(=O)O)NC(=O)C(CC(=O)N)N
  • Aliases: L-​Leucine, L-​asparaginyl-​L-​α-​aspartyl-​L-​α-​glutamyl-​L-​cysteinyl-​L-​α-​glutamyl-​L-​leucyl-​L-​cysteinyl-​L-​valyl-​L-​asparaginyl-​L-​valyl-​L-​alanyl-​L-​cysteinyl-​L-​threonylglycyl-​L-​cysteinyl-​, cyclic (4→12)​,​(7→15)​-​bis(disulfide); 105: PN: WO2012037380 SEQID: 105 claimed protein; 1: PN: US20100152118 SEQID: 1 claimed protein; 1: PN: WO2008151257 SEQID: 1 claimed protein; 1: PN: WO2010065751 SEQID: 1 claimed protein; 1: PN: WO2011069038 SEQID: 1 claimed sequence; 1: PN: WO2012037380 SEQID: 1 claimed protein; 1: PN: WO2014131024 SEQID: 1 claimed protein; 1: PN: WO2015054500 SEQID: 1 claimed protein; 1: PN: WO2015054649 SEQID: 1 claimed protein; 20: PN: WO02078683 SEQID: 20 claimed protein; 78: PN: WO2010065751 SEQID: 105 claimed protein; 7: PN: WO2015054500 SEQID: 105 claimed protein; 8: PN: WO2015054500 SEQID: 106 claimed protein; 9: PN: WO2015054500 SEQID: 107 claimed protein; SP 304; Trulance
  • Cas Number: 467426-54-6
  • Molecular Weight: 1681.89
  • Molecular Formula: C65H104N18O26S4
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