Human CD39 Protein, Mouse IgG2a Fc Tag (active enzyme)

DESCRIPTION

CD39 is also known as Ectonucleoside triphosphate diphosphohydrolase 1, ENTPD1, NTPDase 1, Ecto-ATPDase 1, in the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. NTPDase-1 was originally described as CD39, a B lymphocyte cell surface marker, but it is also present on the surface of natural killer cells, T cells, and some endothelial cells.Regulatory T cells(Tregs) mediate immunosuppression through multiple, non-redundant, cell-contact dependent and independent mechanisms, a growing body of evidence suggests an important role for the CD39-CD73-adenosine pathway. CD39 ectonucleotidase is the rate-limiting enzyme of a cascade leading to the generation of suppressive adenosine that alters CD4 and CD8 T cell and natural killer cell antitumor activities.

DETAILS

Tag: C-mFc(mIgG2a)
Host: HEK293
Size: 500ug
Buffer: 20 mM Tris, 500 mM Arginine, 150 mM NaCl, pH7.5
Format: Liquid
Purity: 95%
Source: Human CD39, Mouse IgG2a Fc Tag (CD9-H5253) is expressed from human 293 cells (HEK293). It contains AA Thr 38 - Val 478 (Accession # P49961-1).
Storage: -70℃
Category: Bio-Markers & CD Antigens
Molecule: CD39
Accession: NP_001767.3
Conjugate: Unconjugated
Stability: ● The product MUST be stored at -70°C or lower upon receipt; ● -70°C for 3 months under sterile conditions.
Exp Region: Thr 38 - Val 478
Swiss-prot: P49961-1
Package Size: 500ug*1
Characteristics: This protein carries a mouse IgG2a Fc tag at the C-terminus. The protein has a calculated MW of 77.3 kDa. The protein migrates as 95-110 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 0.1 EU per μg
Molecular Weight: 77.3 kDa
Shipping Condition: Dry ice
Species Reactivity: Human
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