DESCRIPTION

• Notes: License Disclosure: Visit bpsbioscience.com/license for the label license and other key information about this product.  Troubleshooting Guide: Visit bpsbioscience.com/cell-line-faq for detailed troubleshooting instructions. For all further questions, please email support@bpsbioscience.com.
• Shiptemp: -80°C (dry ice)
• Synonyms: CLDN18, UNQ778, PRO1572, Claudin 18.2
• Warnings: Avoid freeze/thaw cycles.
• Category: Cell Signaling/Cell Line
• Background: Claudins are integral membrane proteins and components of tight junction strands which serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets. The claudin-18 gene has two splice variants: claudin-18.1, which is found primarily in the lung, and claudin-18.2, which is expressed exclusively in the stomach. Claudin-18.2 is highly expressed in gastric and pancreatic adenocarcinoma, located in the outer cell membrane, and involved in tumor development and progression. In addition, it has exposed extracellular loops and is available for monoclonal antibody binding. These biological characteristics suggest that it is an ideal target for therapy and have led to the further development of monoclonal antibodies against claudin 18.2, such as Zolbetuximab.
• Description: Recombinant clonal CHO cell line stably expressing full length human claudin 18.2 (claudin 18 isoform 2, CLDN 18.2, gene accession number NM_001002026.3). The stable clonal cell line was selected for different levels of Claudin 18.2 expression (High, Medium, and Low) compared to the parental CHO-K1 cell line.
• Supplied As: Each vial contains 2 x 106 cells in 1 ml of cell freezing medium (BPS Bioscience #79796)
• Unspsc Code: 41106514
• Unspsc Name: Stable mammalian cell lines
• Applications: Test antibodies against Claudin 18.2 and anti-Claudin 18.2 CAR T cells for immunotherapy research and drug discovery. Screen inhibitors or neutralizing antibodies against Claudin 18.2
• Host Species: hamster
• Product Type: Cell Line
• Host Cell Line: CHO-K1 cells, Chinese Hamster Ovary, epithelial-like cells, adherent
• Biosafety Level: BSL-1
• Related Products: 78361, 78527
• Storage Stability: Cells are shipped in dry ice and should immediately be thawed or stored in liquid nitrogen upon receipt. Do not use a -80°C freezer for long term storage.
• Mycoplasma Testing: The cell line has been screened to confirm the absence of Mycoplasma species.
• Scientific Category: Cell Signaling Pathway
• Required Accessories: 60186,79539,79796
• Signed License Required: Yes