Anti-TOX3 / TNRC9 Monoclonal Antibody(Clone: TOX3/1124)

DESCRIPTION

It recognizes a 63kDa protein, which is identified as TOX3. It contains a high mobility group (HMG)-box, which regulates Ca2+-dependent transcription in neurons throµgh interaction with the cAMP-response-element-binding protein (CREB). TOX3 appears to be associated with breast cancer susceptibility and is expressed downstream of a cytoprotective cascade together with CITED1, a transcriptional regulator that does not bind directly to DNA. TOX3 is predominantly expressed in the brain and forms homodimers. TOX3 overexpression protects neuronal cells from cell death caused by endoplasmic reticulum stress or BAX overexpression throµgh the induction of anti-apoptotic transcripts and repression of pro-apoptotic transcripts.

DETAILS

Gene: TOX3
App Id: ELISA,WB
Gene Id: 27324
Isotype: Mouse IgG1, kappa
Clone Name: TOX3/1124
Uniprot Id: O15405
Host Animal: Mouse
Clonality Id: Monoclonal
Reactivity Id: Human
Product Content: 200 µg/ml of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Alternative Name: TOX3; CAG trinucleotide repeat-containing gene F9 protein; CAGF9; TOX high mobility group box family member 3; Trinucleotide repeat containing 9 (TNRC9)
Application Note: ELISA (For coating, order Ab without BSA); Western Blot (1-2ug/ml);
Storage Condition: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.
Immunogen Information: Recombinant fragment of human TOX3 protein (around aa 251-389) (Exact sequence is proprietary)