mouse monoclonal IgG2a; Siglec-5 Antibody (H-7) is an IgG2a κ mouse monoclonal Siglec-5 antibody (also designated Siglec-5 antibody) that detects the Siglec-5 protein of human origin by WB, IP, IF and ELISA. Siglec-5 Antibody (H-7) is available as both the non-conjugated anti-Siglec-5 antibody form, as well as multiple conjugated forms of anti-Siglec-5 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Two families of mammalian lectin-like adhesion molecules bind glycoconjugate ligands in a sialic acid-dependent manner: the selectins and the sialoadhesins. The sialic acid-binding immunoglobulin superfamily lectins, designated siglecs or sialoadhesins, are immunoglobulin superfamily members recognizing sialylated ligands. Siglec-5 binds equally to alpha2,3-linked and alpha2,6-linked sialic acid. There exist four isoforms of hSiglec-5 possessing three (hSiglec-5-3L and -3C) or four (hSiglec-5-4L and -4S) extracellular domains linked to long (hSiglec-5-3L and -4L) or short (hSiglec-5-4S) cytoplasmic tails or existing as a soluble isoform (hSiglec-5-3C). Siglec-5 is expressed by monocytes and neutrophils, but is absent from leukemic cell lines representing early stages of myelomonocytic differentiation. Siglec-5 may play a role in the diagnosis and monitoring of acute myeloid leukemia (AML).