DESCRIPTION

• Notes: License Disclosure: Purchase of this cell line grants you with a 10-year license to use this cell line in your immediate laboratory, for research use only. This license does not permit you to share, distribute, sell, sublicense, or otherwise make the cell line available for use to other laboratories, departments, research institutions, hospitals, universities, or biotech companies. The license does not permit use of this cell line in humans or for therapeutic or drug use. The license does not permit modification of the cell line in any way. Inappropriate use or distribution of this cell line will result in revocation of the license and result in an immediate cease of sales and distribution of BPS products to your laboratory. BPS does not warrant the suitability of the cell line for any particular use, and does not accept any liability in connection with the handling or use of the cell line. Modifications of this cell line, transfer to another facility, or commercial use of the cells may require a separate license and additional fees; contact sales@bpsbioscience.com for details. Publications using this cell line should reference BPS Bioscience, Inc., San Diego.
• Format: Each vial contains 2 x 10^6 cells in 1 ml of 10% DMSO
• Species: Human
• Shiptemp: -80°C (dry ice)
• Category: Immunotherapy/Cell Line
• Background: Glucocorticoid-induced TNFR-related protein (GITR) is a member of the TNFR superfamily, expressed in a number of cells including T cells, natural killer (NK) cells and antigen-presenting cells (APC). GITRL, GITR's natural ligand, is expressed mainly by APCs and GITR:GITRL interaction is important for activation of the immune system. Agonistic antibodies targeting GITR are actively being pursued as potential immuno-oncology therapies.
• Description: Recombinant HEK293 cell expressing firefly luciferase gene under the control of NF-κB response elements with constitutive expression of human OX40 (Tumor Necrosis Factor Receptor Superfamily Member 4, TNFRSF4, and CD134, GenBank Accession No. NM_003327)
• Unspsc Code: 41106514
• Unspsc Name: Stable mammalian cell lines
• Applications: Screen for activators or inhibitors of OX40 signaling in a cellular context and characterize the biological activity of OX40 and its interactions with ligands
• Host Species: human
• Product Type: Cell Line
• Host Cell Line: HEK293
• Biosafety Level: BSL-2
• Related Products: 71185, 72063-1, 79528, 60690, 60187, 79796
• Storage Stability: Store in liquid nitrogen immediately upon receipt.
• Mycoplasma Testing: The cell line has been screened using the PCR-based Venor™GeM Mycoplasma Detection kit (Sigma-Aldrich) to confirm the absence of Mycoplasma species.
• Scientific Category: Immunotherapy
• Required Accessories: 79528,60690,60187,79796
• Signed License Required: Yes