RP01885
Recombinant Mouse CCL21/6Ckine Protein
ABclonal
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DESCRIPTION
C-C Motif Chemokine 21a (CCL21a) is a small secreted cytokine that belongs to the intercrine beta (CCchemokine) family. Mouse CCL21 cDNA encodes a 133 amino acid residue protein with a 23 residue signalpeptide that is cleaved to generate the 110 residue mature protein. Mouse CCL21 has three forms whileCCL21a has Ser-65. CCL21 elicits its effects by binding to a cell surface chemokine receptor known as CCR7 andCXCR3. Mouse CCL21 inhibits hemopoiesis and stimulates chemotaxis. It has chemotactic function in vitro forthymocytes and activated T-cells, but not for B-cells, macrophages, or neutrophils. Mouse CCL21 showspreferential activity towards naive T-cells and may play a role in mediating homing of lymphocytes tosecondary lymphoid organs.
DETAILS
- Tag: C-His
- Source: Pichia
- Gene Id: 18829
- Species: Mouse
- Lead Time: 3-5 weekdays
- Swiss Prot: P84444
- Research Areas: Cytokines & Cytokine Receptors
- Alternative Names: C-C Motif Chemokine 21a; 6Ckine; Beta-Chemokine Exodus-2; Small-Inducible Cytokine A21a;Thymus-Derived Chemotactic Agent 4; TCA4; Ccl21a; Scya21; Scya21a