Glabrol

DESCRIPTION

A flavonoid with diverse biological activities; inhibits NA activity in oseltamivir-sensitive and -resistant H1N1 influenza strains (IC50s = 0.51 and 14.1 µM, respectively), as well as PTP1B, ACAT, and DGAT (IC50s = 0.31, 24.6, and 8 µM, respectively); cytotoxic to MCF-7, SW480, and HepG2 cells (IC50s = 7.62, 5.15, and 2.83 µM, respectively); active against MRSA (MIC50 = 2 µg/ml); binds to the benzodiazepine receptor (Ki = 1.63 µM) and increases pentobarbital-induced sleep duration in mice at 50 mg/kg, an effect that can be reversed by flumazenil

DETAILS

Inchi: InChI=1S/C25H28O4/c1-15(2)5-7-17-13-18(8-11-21(17)26)24-14-23(28)20-10-12-22(27)19(25(20)29-24)9-6-16(3)4/h5-6,8,10-13,24,26-27H,7,9,14H2,1-4H3/t24-/m0/s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Antivirals|Neuraminidase Inhibitors||Product Type|Biochemicals|Ion Channel Modulation||Product Type|Biochemicals|Lipids|Polyketides||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Polyketides||Product Type|Biochemicals|Small Molecule Inhibitors|Acyltransferases||Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Death||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cell Biology|Cell Signaling||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|MRSA||Research Area|Infectious Disease|Viral Diseases|Influenza||Research Area|Lipid Biochemistry|Glycerolipids|Acyltransferases||Research Area|Lipid Biochemistry|Sterol Lipids||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms
Smiles: C/C(C)=C\CC1=C2C(C(C[C@](C3=CC(C/C=C(C)\C)=C(C=C3)O)([H])O2)=O)=CC=C1O
Inchikey: CUFAXDWQDQQKFF-DEOSSOPVSA-N
Cas Number: 59870-65-4
Formulation: A solid
Item Origin: Plant/Glycyrrhiza uralensis Fisch
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C25H28O4
Formula Weight: 392.5
Shelf Life Days: 1460