mouse monoclonal IgG1; CA XIV Antibody (A-4) is an IgG1 κ mouse monoclonal CA XIV antibody (also designated CAXiV antibody, Carbonic anhydrase XIV antibody, carbonate dehydratase metalloenzyme antibody, zinc metalloenzyme antibody, cell membrane-associated carbonic anhydrase 14 antibody, or transmembrane dimeric zinc metalloenzyme antibody) that detects the CA XIV protein of mouse, rat and human origin by WB, IP, IF and ELISA. CA XIV Antibody (A-4) is available as both the non-conjugated anti-CA XIV antibody form, as well as multiple conjugated forms of anti-CA XIV antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Carbonic anhydrases (CAs) are members of a large family of zinc metallo-enzymes that catalyze the reversible hydration of carbon dioxide. CAs are involved in a variety of biological processes, including respiration, calcification, acid-base balance and bone resorption, as well as the formation of aqueous humor, cerebrospinal fluid, saliva and gastric juice. They show extensive diversity in distribution and in their subcellular localization. The human CA2 gene, which maps to chromosome 8q22, encodes CA II, a cytoplasmic protein that has the highest turnover rate and widest tissue distribution of any known human CA isozyme. The human CA4 gene, which maps to chromosome 17q23, encodes CA IV, a membrane-anchored isozyme that is expressed on the luminal surfaces of pulmonary capillaries and proximal renal tubules. The human CA9, CA12 and CA14 genes, which map to chromosomes 9p13-p12, 15q22 and 1q21, respectively, encode transmembrane proteins that have unique patterns of tissue-specific expression. CA IX is specifically expressed in clear-cell renal carcinomas, whereas CA XII is highly expressed in normal tissues, such as kidney, colon and pancreas. Human CA XIV is also expressed in normal tissues, such as brain, but differs from CA XII in its expression pattern.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.