Cynomolgus / Rhesus macaque Fas Ligand / TNFSF6 Protein, His Tag, premium grade

DESCRIPTION

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

DETAILS

Tag: N-10×His
Host: HEK293
Size: 1mg
Buffer: PBS, pH7.4
Format: Powder
Purity: 90%
Source: Cynomolgus / Rhesus macaque Fas Ligand Protein, His Tag, premium grade (FAL-H5246) is expressed from human 293 cells (HEK293). It contains AA Pro 133 - Leu 280 (Accession # P63308-1).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: FAS Ligand
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Pro 133 - Leu 280
Swiss-prot: P63308-1
Package Size: 500ug*2
Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 18.8 kDa. The protein migrates as 27-33 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 18.8 kDa
Shipping Condition: RT
Species Reactivity: Cynomolgus / Rhesus macaque
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