14926
L-685,458
Cayman Chemical
DESCRIPTION
A γ-secretase inhibitor (IC50 = 17 nM); selective for γ-secretase over HIV-1, cathepsin D, trypsin, HepC3 NS3, papain, and calpain I proteases (IC50s = >1,000 nM); inhibits production of Aβ40 and Aβ42 in Neuro2A cells transfected with human APP (IC50s = 402 and 775 nM, respectively); blocks hypoxia-induced activity of the Notch-responsive reporters 12xCSL and CBF1 in isolated rat intervertebral disc cells
DETAILS
- Inchi: InChI=1S/C39H52N4O6/c1-26(2)21-33(37(47)41-32(35(40)45)24-29-19-13-8-14-20-29)42-36(46)30(22-27-15-9-6-10-16-27)25-34(44)31(23-28-17-11-7-12-18-28)43-38(48)49-39(3,4)5/h6-20,26,30-34,44H,21-25H2,1-5H3,(H2,40,45)(H,41,47)(H,42,46)(H,43,48)/t30-,31+,32
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cell Biology|Cell Signaling|Notch Signaling||Research Area|Cell Biology|Proteolysis|Lysosomal Proteases||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease
- Smiles: CC(OC(N[C@H]([C@@H](C[C@H](C(N[C@H](C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)CC(C)C)=O)CC2=CC=CC=C2)O)CC3=CC=CC=C3)=O)(C)C
- Inchikey: MURCDOXDAHPNRQ-ZJKZPDEISA-N
- Cas Number: 292632-98-5
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C39H52N4O6
- Formula Weight: 672.9
- Shelf Life Days: 1460