PAMP 12 (human, porcine)

DESCRIPTION

PAMP 12 (human, porcine) corresponds to amino acids 9 to 20 of proadrenomedullin. and is an endogenous peptide agonist of Mas related GPR X2 (MRGPRX2) with an EC50 of 57.2 nM. PAMP 12 (human, porcine) can cause hypotension through inhibiting catecholamine secretion from sympathetic nerve endings and adrenal chromaffin cells. PAMP 12 (human, porcine) displays potent antimicrobial activity against standard bacterial strains, with a mechanism of action not involving the microbial cell membrane but instead targeting binding to bacterial DNA.

DETAILS

Mf: C77H119N25O14
Mw: 1618.95
Refs: Kuwasako (1997) Purification and characterization of PAMP-12 (PAMP[9-20]) in porcine adrenal medulla as a major endogenous biologically active peptide. FEBS Lett. 414(1) 105 PMID: 9305741Kamohara et al (2005) Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides. Biochem.Biophys.Res.Commun. 330 1146 PMID: 15823563Ajish (2020) Proadrenomedullin N-terminal 20 peptide (PAMP) and its C-terminal 12-residue peptide, PAMP(9-20): Cell selectivity and antimicrobial mechanism. Biochem Biophys Res Commun. 527(3) 744 PMID: 32439180PubChem record - PAMP-12 (human, porcine)Related areas All peptides >All mas-related G protein-coupled receptor modulators >All cardiovascular research categories >All antimicrobial agents >
Cas No: 196305-05-2
Purity: >95% by hplc
Target: Mas-related G protein-coupled receptors,Antibacterials
Storage: Store dry, frozen and in the dark
Sequence: FRKKWNKWALSR-NH2
Appearance: Freeze dried solid
Othernames: PAMP (9-20)
Solubility: Soluble to 1 mg/ml in water
Producttype: Peptides
Modifications: C-terminal amide
Threelettersequence: H-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2