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OAC-2

Biogems

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DETAILS

  • Purity: ≥98%
  • Synonyms: OAC2, AK175881, N-1h-indol-5-yl-benzamide
  • Cas Number: 6019-39-2
  • References: Cao, N., Huang, Y., Zheng, J., Spencer, C. I., Zhang, Y., Fu, J. D., ... & Ma, T. (2016). Conversion of human fibroblasts into functional cardiomyocytes by small molecules. Science, 352(6290), 1216-1220. Li, W., Tian, E., Chen, Z. X., Sun, G., Ye, P., Yang, S., ... & Wang, C. (2012). Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proceedings of the National Academy of Sciences, 109(51), 20853-20858. Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. cell, 131(5), 861-872.
  • Application: FA
  • Formulation: Crystalline solid
  • Chemical Name: N-(1H-indol-5-yl)benzamide
  • Molecular Weight: 236.3
  • Molecular Formula: C15H12N2O
  • Storage Conditions: Product should be kept at -20°C.
  • Pubchem Openeye Can Smiles: C1=CC=C(C=C1)C(=O)NC2=CC3=C(C=C2)NC=C3

DESCRIPTION

OAC-2 is an Octamer-binding transcription factor 4 (OCT4) activator. It is reported to enhance the reprogramming efficiency of induced pluripotent stem cells (iPSCs) from fibroblasts and induces cardiomyocyte-like cells generation from fibroblasts when used in conjunction with other small molecules.