GSTM3 Antibody (N-term) Blocking Peptide

DETAILS

Format: Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed.
Gene Id: 2947
Category: Peptides; Blocking Peptides
Subtitle: Synthetic peptide
Gene Name: GSTM3
Other Names: Glutathione S-transferase Mu 3, GST class-mu 3, GSTM3-3, hGSTM3-3, GSTM3, GST5
Availability: 2 weeks
Bio Background: Cytosolic and membrane-bound forms of glutathioneS-transferase are encoded by two distinct supergene families. Atpresent, eight distinct classes of the soluble cytoplasmicmammalian glutathione S-transferases have been identified: alpha,kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes aglutathione S-transferase that belongs to the mu class. The muclass of enzymes functions in the detoxification of electrophiliccompounds, including carcinogens, therapeutic drugs, environmentaltoxins and products of oxidative stress, by conjugation withglutathione. The genes encoding the mu class of enzymes areorganized in a gene cluster on chromosome 1p13.3 and are known tobe highly polymorphic. These genetic variations can change anindividual's susceptibility to carcinogens and toxins as well asaffect the toxicity and efficacy of certain drugs. Mutations ofthis class mu gene have been linked with a slight increase in anumber of cancers, likely due to exposure with environmentaltoxins. Alternative splicing results in multiple transcriptvariants.
Bio References: Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Malik, M.A., et al. Nutr Cancer 62(6):734-742(2010)Salinas-Souza, C., et al. Pharmacogenet. Genomics 20(8):507-515(2010)Teixeira, D., et al. Braz. J. Med. Biol. Res. 43(7):677-680(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :
Primary Accession: P21266