mouse monoclonal IgG2a; Neuregulin-3 Antibody (D-3) is an IgG2a κ mouse monoclonal Neuregulin-3 antibody (also designated NRG3 antibody) that detects the Neuregulin-3 protein of mouse, rat and human origin by WB, IP, IF and ELISA. Neuregulin-3 Antibody (D-3) is available as both the non-conjugated anti-Neuregulin-3 antibody form, as well as multiple conjugated forms of anti-Neuregulin-3 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The ErbB/HER family of receptor tyrosine kinases consists of four receptors that bind a large number of growth factor ligands sharing an epidermal growth factor-(EGF)-like motif. The neuregulins (NRGs) are a diverse family of proteins that arise by alternative splicing from a single gene. These proteins play an important role in controlling the growth and differentiation of glial, epithelial, and muscle cells. Whereas ErbB-1 binds seven different ligands whose prototype is EGF, the four families of neuregulins activate ErbB-3 and/or ErbB-4. Neuregulin-1 (also known as heregulin) has diverse functions in neural development, and one of them is to up-regulate the expression of acetylcholine receptors at muscle fibers during the formation of neuromuscular junctions. Neuregulin-2 exhibits a distinct expression pattern in adult brain and developing heart. Neuregulin-3 is expressed in cell lines derived from breast cancer and is a potential regulator of normal and malignant breast epithelial cells. Neuregulin-4 is detected in the adult pancreas and weakly in muscle.