Rat Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer Protein, His Tag&Tag Free

DESCRIPTION

Integrin alpha 2 beta 1 is one of twelve integrin family adhesion receptors that share the beta 1 subunit. It is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix. Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A and Human echoviruses 1 and 8. DGEA inhibited rotavirus binding to alpha2beta1 and infectivity. In a novel process, integrin-using viruses bind the alpha2 I domain of alpha2beta1 via DGE in VP4 and interact with alphaXbeta2 (via GPR) and alphaVbeta3 by using VP7 to facilitate cell entry and infection.

DETAILS

Tag: C-10×His | Native
Host: HEK293
Size: 100ug
Buffer: 50 mM Tris, 150 mM NaCl, pH8.0
Format: Powder
Purity: 90%
Source: Rat ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free (IT1-R52W9) is expressed from human 293 cells (HEK293). It contains AA Tyr 27 - Gly 1130 (ITGA2) & Gln 21 - Asp 729 (ITGB1) (Accession # A0A0G2K470-1 (ITGA2) & P49134-1 (ITGB1)).
Storage: -20℃
Category: Bio-Markers & CD Antigens
Molecule: Integrin alpha 2 beta 1
Accession: XP_345157.5 |
Conjugate: Unconjugated
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Tyr 27 - Gly 1130 (ITGA2) & Gln 21 - Asp 729 (ITGB1)
Swiss-prot: A0A0G2K470-1 (ITGA2) & P49134-1 (ITGB1)
Package Size: 100ug*1
Characteristics: Rat ITGA2&ITGB1 Heterodimer Protein, His Tag&Tag Free, produced by co-expression of ITGA2 and ITGB1, has a calculated MW of 127.6 kDa (ITGA2) and 83.7 kDa (ITGB1). Subunit ITGA2 is fused with an acidic tail at the C-terminus and followed by a polyhistidine tag and subunit ITGB1 contains no tag but a basic tail at the C-terminus. The reducing (R) protein migrates as 150-180 kDa (ITGA2) and 100-130 kDa (ITGB1) respectively due to glycosylation.
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 127.6 kDa (ITGA2) & 83.7 kDa (ITGB1)
Shipping Condition: RT
Species Reactivity: Rat
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