10-036
Oseltamivir . phosphate
ProSci
DESCRIPTION
Oseltamivir phosphate is an influenza viral neuraminidase inhibitor. It is an antiviral prodrug targeted against the influenza viruses. Once hydrolyzed in the liver to its active metabolite, oseltamivir carboxylate, it can competitively inhibit viral neuraminidase (IC50s=0.1-4.9nM for influenza neuraminidases A and B). The enzyme cleaves the sialic acid which is found on glycoproteins on the surface of human cells that helps new virions to exit the cell. Thus oseltamivir is blocking the release of new viral particles from a host cell. Oseltamivir phosphate is used clinically to treat influenza A and influenza B and to prevent flu after exposure. It potentially could be used to reduce the spread of the SARS-CoV-2 and counteract against the transmission of COVID-19
DETAILS
- Cas: 204255-11-8
- Purity: greater than or equal to 98% (HPLC)
- Smiles: O=P(OO)=O.N[C@@H]1[C@@H](NC(C)=O)[C@H](OC(CC)CC)C=C(C(OCC)=O)C1.[HH]
- Formula: C16H28N2O4 . H3PO4
- Storage: Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.
- Identity: Determined by 1H-NMR.
- Shipping: Room Temp
- Inchi Key: POPJIXMLXGJJOV-ZFSDTUNKSA-N
- Solubility: Soluble in DMSO (50mg/ml).
- Physical State: Lyophilized
- Additional Names: GS-4104; Ro 64-0796/002; Tamiflu
- Predicted Molecular Weight: 312.4 . 98.0
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