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Animal-Free Recombinant Murine IL-22



IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10Rbeta/CRF2-4 and IL-22R, both of which are members ofthe class II cytokine-receptor family. Recombinant Murine IL-22 is a 33.4 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.


  • Gene Id: 50929
  • Uniprot: Q9JJY9
  • Activity: Determined by its ability to induce STAT3 activation in COLO 205 cells. The expected ED50 for this effect is 150-400 pg/ml.
  • Category: RUO Cytokines
  • Subcategory: Animal-Free Cytokines
  • Research Areas: Immune System
  • Alternative Names: Interleukin-22, IL-TIF, Cytokine ZCYTO18
  • Species of Origin: Murine
  • Expression System Source: E.coli