23412
Olmesartan
Cayman Chemical
DESCRIPTION
An AT1 receptor antagonist (IC50 = 0.0077 µM for the bovine adrenal cortex receptor) and active metabolite of olmesartan medoxomil; selective for AT1 over AT2 (IC50 = >100 µM for the bovine cerebellar receptor); reduces contraction of isolated guinea pig aorta induced by angiotensin II (pD2 = 9.9); reduces the angiotensin II-induced pressor response in conscious normotensive rats at 0.01 and 0.03 mg/kg, i.v.
DETAILS
- Inchi: InChI=1S/C24H26N6O3/c1-4-7-19-25-21(24(2,3)33)20(23(31)32)30(19)14-15-10-12-16(13-11-15)17-8-5-6-9-18(17)22-26-28-29-27-22/h5-6,8-13,33H,4,7,14H2,1-3H3,(H,31,32)(H,26,27,28,29)
- Purity: ≥98%
- Raptas: Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Cardiovascular System|Lipids & Lipoproteins||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias
- Smiles: OC(C)(C)C1=C(C(O)=O)N(CC2=CC=C(C3=CC=CC=C3C4=NN=NN4)C=C2)C(CCC)=N1
- Inchikey: VTRAEEWXHOVJFV-UHFFFAOYSA-N
- Cas Number: 144689-24-7
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C24H26N6O3
- Formula Weight: 446.5
- Shelf Life Days: 1460