YM-53601

DESCRIPTION

A squalene synthase inhibitor (IC50s = 79 and 90 nM in HepG2 cells and rat liver microsomes, respectively); inhibits cholesterol biosynthesis in rats (ED50 = 32 mg/kg); dose-dependently reduces plasma triglyceride and non-HDL cholesterol levels in hamsters fed both normal and high-fat diets; reduces viral RNA, core and NS3 protein production, and secreted viral particles in Huh-7.5.1-8 cells infected with HCV strain JFH-1 without affecting cell viability at 0.5-1.5 μM; confers protection against cytotoxicity induced by the bacterial pore-forming toxin pneumolysin in HBE1 and NHBE cells at 1-10 μM

DETAILS

Inchi: InChI=1S/C21H21FN2O.ClH/c22-19(18-12-24-9-7-14(18)8-10-24)13-25-15-5-6-17-16-3-1-2-4-20(16)23-21(17)11-15;/h1-6,11,14,23H,7-10,12-13H2;1H/b19-18-;
Purity: ≥98%
Raptas: Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|Hepatitis
Smiles: F/C(COC1=CC2=C(C(C=CC=C3)=C3N2)C=C1)=C4C5CCN(CC5)C\4.Cl
Inchikey: JWXYVHMBPISIJQ-TVWXOORISA-N
Cas Number: 182959-33-7
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C21H21FN2O • HCl
Formula Weight: 372.9
Shelf Life Days: 730