NKA-M52H5-100ug NKA-M52H5-1mg
Mouse NKG2A / CD159a Protein, His Tag
ACROBiosystems
Image
![](https://www.acrobiosystems.com/static/main/products/images/sds/NKA-M52H5.jpg)
Image
![](https://www.acrobiosystems.com/static/main/products/images/sds/NKA-M52H5.jpg)
DESCRIPTION
NKG2A/CD159a is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors that inhibits innate immune system activation, also known as KLRC1, CD159a, NK cell receptor A and NKG2-A/NKG2-B type II integral membrane protein. NKG2A marks a unique immune effector subset preferentially co-expressing the tissue-resident CD103 molecule, but not immune checkpoint inhibitors. NKG2A blockade therapy operated through CD8 T cells, but not NK cells. The increase in NKG2A expression might be induced by IL-10, which was present at a high level in the plasma of HCC patients. Blocking IL-10 could specifically inhibit NKG2A expression in NK cells. These findings indicate that NKG2A expression is influenced by factors from cancer nests and contributes to NK cell exhaustion, suggesting that NKG2A blockade has the potential to restore immunity against liver tumors by reversing NK cell exhaustion.
DETAILS
- Tag: N-10×His
- Host: HEK293
- Size: 100ug
- Buffer: PBS, pH7.4
- Format: Powder
- Purity: 90%
- Source: Mouse NKG2A, His Tag (NKA-M52H5) is expressed from human 293 cells (HEK293). It contains AA Thr 95 - Ile 244 (Accession # Q9Z202-1).
- Storage: -20℃
- Category: Other Recombinant Proteins
- Molecule: NKG2A
- Accession: NP_001129540.1
- Conjugate: Unconjugated
- Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 3 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
- Exp Region: Thr 95 - Ile 244
- Swiss-prot: Q9Z202-1
- Package Size: 100ug*1
- Characteristics: This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 19.1kDa. The protein migrates as 33-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
- Endotoxin Level: 1.0 EU per μg
- Molecular Weight: 19.1kDa
- Shipping Condition: RT
- Species Reactivity: Mouse
- Extra Shippinghandling Fee: Please see 'Shipping-and-Payments' sheet. Website: https://www.acrobiosystems.com/A48-Shipping-and-Payments.html