79794
Scientist.com Supplier
LCK Assay Kit
BPS Bioscience
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DESCRIPTION:
The LCK Assay Kit is designed to measure LCK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
DETAILS
- Shiptemp: -80°C (dry ice)
- Synonyms: LCK, Leukocyte C-Terminal Src Kinase, T-Lymphocyte Specific Protein Tyrosine Kinase, lck
- Category: Kinase/Assay Kit
- Background: LCK is a tyrosine kinase that phosphorylates the CD3 receptor and is essential for T cell development and activation. LCK also associates with the cytoplasmic domains of the CD4 and CD8 glycoproteins and interacts with the beta-chain of the interleukin-2 receptor. LCK inhibitors are being investigated as a promising therapeutic approach to autoimmune disease and other inflammatory disorders.
- References: 1. Yu, C.-L., Jove, R., and Burakoff, S.J. 1997. "Constitutive activation of the Janus kinase-STAT pathway in T lymphoma overexpressing the LCK protein tyrosine kinase." J. Immunology 159 (11): 5206-5210. 2. Veillette, A., et al. 1989. "Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56LCK." Nature 338(6212): 257-259.
- Description: The LCK Assay Kit is designed to measure LCK activity for screening and profiling applications using Kinase-Glo® MAX as a detection reagent.
- Methodology: Chemiluminescent
- Supplied As: The LCK Assay Kit comes in a convenient 96-well format, with enough purified recombinant LCK, Protein Tyrosine Kinase Substrate (Poly-Glu,Tyr 4:1), ATP, and kinase assay buffer for 96 enzyme reactions.
- Unspsc Code: 41105332
- Unspsc Name: Protein chemiluminescent detection reagents or kits or substrates
- Applications: Useful for studying enzyme kinetics and screening small molecular inhibitors for drug discovery and HTS applications.
- Product Type: Assay Kit
- Biosafety Level: Not applicable (BSL-1)
- Related Products: 40470, 79681, 79744, 79800-P, 78487
- Storage Stability: Up to 6 months when stored as recommended.
- Scientific Category: Kinase
- Instructions For Use: See assay protocol for detailed instructions.