mouse monoclonal IgG1; TGase2 Antibody (4G3) is an IgG1 κ mouse monoclonal TGase2 antibody that detects TGase2 first binding domain of mouse, rat and human origin by WB, IP, IF and IHC(P). TGase2 Antibody (4G3) is available as the non-conjugated anti-TGase2 antibody form, as well as multiple conjugated forms of anti-TGase2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Terminally differentiating mammalian epidermal cells acquire an insoluble, 10 to 20 nm thick protein deposit on the intracellular surface of the plasma membrane known as the cross-linked cell envelope (CE). The CE is a component of the epidermis that is generated through formation of disulfide bonds and g-glutamyl-lysine isodipeptide bonds, which are formed by the action of transglutaminases (TGases). TGases are intercellularly localizing, Ca2+-dependent enzymes that catalyze the formation of isopeptide bonds by transferring an amine on to glutaminyl residues, thereby cross-linking glutamine residues and lysine residues in substrate proteins. TGases influence numerous biological processes, including blood coagulation, epidermal differentiation, seminal fluid coagulation, fertilization, cell differentiation and apoptosis. Human keratinocyte transglutaminase (TGase1) is a membrane associated, 817 amino acid protein. Human tissue transglutaminase (TGase2) is an endothelial cell specific, 687 amino acid protein.0

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.