DESCRIPTION

• Notes: Troubleshooting Guide: Visit bpsbioscience.com/assay-kits-faq for detailed troubleshooting instructions. For all further questions, please email support@bpsbioscience.com
• Uniprot: Q9UQB9
• Shiptemp: -80°C (dry ice)
• Synonyms: AURKC, AIE2, AIK3, AIRK3, ARK3, STK13, Aurora kinase C, Aurora 3, Aurora/IPL1-related kinase 3 (ARK-3; Aurora-related kinase 3), Aurora/IPL1/Eg2 protein 2, Serine/threonine-protein kinase 13, Serine/threonine-protein kinase aurora-C
• Warnings: Avoid freeze/thaw cycles
• Category: Kinase/Assay Kit
• Background: Aurora Kinase C, also known as serine/threonine-protein kinase 13, is part of the Aurora subfamily. Aurora Kinase C is a CPC (chromosomal passenger complex) protein and forms a complex with Aurora Kinase B and centromere proteins. It plays a role in microtubule organization during mitosis and meiosis, mostly in meiosis. It has a pattern of expression and subcellular localization that varies with the cell cycle stage, in agreement with its role in cell cycle regulation. It has oncogenic activity and is overexpressed in cancer cell lines, by performing similar functions to Aurora Kinase B and other still unknown mechanisms. Mutations that inactivate this protein result in male infertility, being the main cause of infertility in North African men. The use of inhibitors can increase the effectiveness of chemotherapy and has been shown to stop the progress and growth of several cancers. Further studies will elucidate the exact mode of action of Aurora Kinase C in cancer development and progression and open new therapeutic avenues.
• References: Tang A., et al., 2017 Oncotarget 8(14):23937-23954.
• Description: The Chemi-Verse™ Aurora Kinase C Assay Kit is a luminescence assay designed to measure Aurora Kinase C activity for screening and profiling applications using ADP-Glo™ as a detection reagent. The assay kit comes in a convenient 96-well format, with enough purified recombinant Aurora Kinase C, kinase substrate, ATP, and kinase assay buffer for 100 enzyme reactions.
• Methodology: Luminescent
• Unspsc Code: 41105332
• Unspsc Name: Protein chemiluminescent detection reagents or kits or substrates
• Applications: Study enzyme kinetics and screen small molecule inhibitors for drug discovery and high throughput screening (HTS) applications.
• Product Type: Assay Kit
• Biosafety Level: Not applicable (BSL-1)
• Related Products: 40002, 40004, 100112, 82095, 82094
• Contraindications: The final concentration of DMSO in the assay should not exceed 1%.
• Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
• Scientific Category: Kinases