sc-56341 SAMPLE sc-56341
Promo Available
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p57 Kip2 (KP39)
Santa Cruz Biotechnology
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DESCRIPTION
mouse monoclonal IgG2b; p57 Kip2 Antibody (KP39) is an IgG2b κ mouse monoclonal p57 Kip2 antibody (also designated p57 antibody, CDKN1C antibody, KIP2 antibody or p57Kip2 antibody) that detects the p57 Kip2 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. p57 Kip2 Antibody (KP39) is available as both the non-conjugated anti-p57 Kip2 antibody form, as well as multiple conjugated forms of anti-p57 Kip2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Cell cycle progression is regulated by a series of cyclin-dependent kinases that consist of catalytic subunits designated Cdks and activating subunits designated cyclins. Orderly progression through the cell cycle requires the activation and inactivation of different cyclin-Cdks at appropriate times. A series of proteins has been described that function as mitotic inhibitors. These include p21 Waf1/Cip1, the levels of which are elevated upon DNA damage in G1 in a p53-dependent manner; p16 INK4A; and p16 INK4A-related inhibitors, designated p15 INK4B, p18 INK4C and p19 INK4D. A p21 Waf1/Cip1-related protein, p27, has been described as a negative regulator of G1 progression and has been speculated to function as a possible mediator of TGFβ-induced G1 arrest. A member of the p21 Waf1/Cip1/p27 family of mitotic inhibitory proteins, p57 Kip2 (also designated p57 and Kip2), is a potent, tight-binding cyclin-dependent inhibitor of several G1 cyclin/Cdk complexes. Overexpression of p57 Kip2 arrests cells in G1. Unlike p21 Waf1/Cip1, p57 Kip2 is not regulated by p53.
DETAILS
- Host: mouse
- Type: Primary
- Uniprot: P49918
- Clonality: Monoclonal
- Conjugate: unconjugated
- Applications: WB, IP, IF, IHC(P), ELISA
- Human Gene Id: 1028
- Mouse Gene Id: 12577
- Protein Target: p57 Kip2
- Human Gene Name: CDKN1C
- Mouse Gene Name: Cdkn1c
- Species Reactivity: mouse, rat, human
PROMOTION TERMS
Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.
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