E2693Mo
Mouse Mitochondrial Amidoxime-Reducing Component 1, MARC1 ELISA Kit
Bioassay Technology Laboratory
DESCRIPTION
Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.
DETAILS
- Gene Id: 66112
- Uniprot: Q9CW42
- Lead Time: 3 days
- Assay Type: Sandwich
- Sample Type: Serum, plasma, cell culture supernates
- Sensitivity: 9.96ng/L
- Detection Range: 20-4500ng/L
- Detection Method: ELISA
- Species Reactivity: Mouse