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E2693Mo

Mouse Mitochondrial Amidoxime-Reducing Component 1, MARC1 ELISA Kit

Bioassay Technology Laboratory

DESCRIPTION

Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles. As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability. May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis. Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction.

DETAILS

  • Gene Id: 66112
  • Uniprot: Q9CW42
  • Lead Time: 3 days
  • Assay Type: Sandwich
  • Sample Type: Serum, plasma, cell culture supernates
  • Sensitivity: 9.96ng/L
  • Detection Range: 20-4500ng/L
  • Detection Method: ELISA
  • Species Reactivity: Mouse