DESCRIPTION

• Category: REAGENTS
• Keywords: PPBIOPRO, Transfection; virus production; virus; Bioproduction; DNA transfection; mammalian cells; cell; HEK-293; Transient gene expression; reagent; transfection reagent; expression; chemically defined; viral vector; lentivirus; AAV; adeno associated virus; large scale
• Paragraph 1: PEIpro® transfection reagent is the leading chemical-based DNA transfection reagent that offers flexibility and scalability to develop a robust and sustainable Process Development for viral vector production. PEIpro® benefits from extensive research development in PEI polymer chemistry and formulation to achieve highest transfection efficiency in both adherent and suspension cell culture systems. Protocols established with PEIpro® during Process Development are directly implementable for large-scale manufacturing of preclinical and clinical batches of viral vectors with the higher quality grades of PEIpro®: PEIpro®-HQ and PEIpro®-GMP.
• Paragraph 2: With its unique property to efficiently condense several plasmids of different sizes, PEIpro® transfection reagent is ideal for optimal co-transfection of several plasmids containing the gene of interest and necessary viral components to produce full recombinant virions. PEIpro® has benefited from extensive developments that made it the unique PEI-based transfection reagent that can offer the flexibility and robustness that is needed during Process Development and Scale-up; it is compatible with commercially available adherent and suspension virus production systems for lentivirus and AAV viral vectors
• Bullet Point 1: Optimized PEI-based transfection reagent for scalable virus production
• Bullet Point 2: Superior viral titers compared to other commercial PEIs and Calcium Phosphate
• Bullet Point 3: Suitable for Process Development of large-scale virus production
• Bullet Point 4: Reliable and secure supply
• Manufacturer Sku: 101000017