Ciprostene (calcium salt)

DESCRIPTION

Ciprostene is the 9β-methyl analog of carbaprostacyclin and a stable analog of PGI2. Ciprostene exhibits biological activity similar to PGI2, but is 30-fold less potent. In patas monkeys, ciprostene induces hypotension and causes tachycardia when administered at a dose of 0.16 µg/kg/min.{4373} In addition, ciprostene inhibits ADP-induced platelet aggregation ex vivo and in vitro with ID50 values of 9.1 µg/kg/min and 60 ng/ml, respectively.{4373,4375}

DETAILS

Inchi: InChI=1S/3C22H36O4.Ca/c3*1-3-4-5-9-17(23)11-12-18-19-13-16(8-6-7-10-21(25)26)14-22(19,2)15-20(18)24;/h3*8,11-12,17-20,23-24H,3-7,9-10,13-15H2,1-2H3,(H,25,26);/q;;;+2/p-3/b3*12-11+,16-8-;/t3*17-,18+,19+,20+,22-;/m000./s1
Purity: ≥98%
Raptas: Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypertension||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
Smiles: CCCCC[C@H](O)/C=C/[C@H]1[C@H](O)C[C@@]2(C)[C@@H]1C/C(C2)=C/CCCC([O-])=O.CCCCC[C@H](O)/C=C\[C@H]3[C@H](O)C[C@@]4(C)[C@@H]3C/C(C4)=C\CCCC([O-])=O.[Ca+2]
Inchikey: FWIIJCPYORKGGH-LOWTZELISA-K
Cas Number: 81703-55-1
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: [C22H35O4]2 • Ca2+
Formula Weight: 767.1
Shelf Life Days: 180