mouse monoclonal IgG2a; VR1 Antibody (E-8) is an IgG2a κ mouse monoclonal VR1 antibody (also designated Trpv1 antibody) that detects the VR1 protein of mouse and rat origin by WB, IP, IF and ELISA. VR1 Antibody (E-8) is available as both the non-conjugated anti-VR1 antibody form, as well as multiple conjugated forms of anti-VR1 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Vanilloid receptor 1 (VR1), also designated capsaicin receptor, is a nonselective cation channel, structurally related to members of the TRP family of ion channels. VR1 is activated by capsaicin, the active ingredient in chili peppers, by heat and by an increase in protons at sites of infection, inflammation and ischemia. By creating moderately acidic conditions, protons are able to lower the temperature threshold for VR1 activation, thus identifying VR1 as a molecular integrator of chemical and physical stimuli that elicit pain. VR1 is expressed in primary sensory neurons and vagal nerves and activated VR1 induces the influx of cations, particularly Ca2+ and Na+ ions. The vanilloid receptor may also be a molecular target for endogenous anandamide, in addition to the cannabinoid receptors, in the nervous and cardiovascular systems.

Free sample available. Limit 3 free samples for each full size Santa Cruz Biotechnology primary antibody ordered. All samples must be different. Customer responsible for shipping costs.