DESCRIPTION

• Mw: 46.6 kDa
• Tag: Myc-DDK
• Accn: NM_012407
• Type: Human Tagged ORF Clone Lentiviral Particle
• Refseq: NM_012407.2
• Status: 2 Weeks*
• Symbol: PICK1
• Vector: pLenti-C-Myc-DDK
• Domains: PDZ
• Category: cDNA Clones
• Locus Id: 9463
• Orf Size: 1245 bp
• Synonyms: PICK; PRKCABP
• Refseq Orf: 1248 bp
• Uniprot Id: Q9NRD5
• Refseq Size: 2224 bp
• Availability: 2 Weeks
• Cytogenetics: 22q13.1
• Gene Summary: The protein encoded by this gene contains a PDZ domain, through which it interacts with protein kinase C, alpha (PRKCA). This protein may function as an adaptor that binds to and organizes the subcellular localization of a variety of membrane proteins. It has been shown to interact with multiple glutamate receptor subtypes, monoamine plasma membrane transporters, as well as non-voltage gated sodium channels, and may target PRKCA to these membrane proteins and thus regulate their distribution and function. This protein has also been found to act as an anchoring protein that specifically targets PRKCA to mitochondria in a ligand-specific manner. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
• Sequence Data: ORF Nucleotide Sequence ( show hide ) The ORF insert of this clone is exactly the same as(RC222869).
• Oti Annotation: This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene.
• Oti Disclaimer: The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info
• Protein Families: Druggable Genome
• Mammalian Cell Selection: None