RP00192
Recombinant Human IL-22RA2/IL22BP Protein
ABclonal
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DESCRIPTION
Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22RA2, is a 35-45 kDa secreted glycoprotein in the type II cytokine receptor family (CRF). IL-22BP specifically binds to and inhibits interleukin 22 activity by blocking the interaction of interleukin 22 with its cell surface receptor.IL-22BP is produced by dendritic cells (DC), epithelial cells, activated B cells, and activated monocytes. It is constitutively expressed by DC but is down-regulated during local inflammation and in response to tissue damage. IL-22BP is critical for limiting IL-22 induced epithelial cell proliferation during wound healing, and its deficiency can enable uncontrolled proliferation and enhance tumor development.
DETAILS
- Tag: C-His
- Source: HEK293 cells
- Gene Id: 116379
- Species: Human
- Lead Time: 3-5 weekdays
- Swiss Prot: Q969J5-2
- Research Areas: Interleukin
- Alternative Names: IL22RA2,CRF2-10,CRF2-S1,CRF2X,IL-22BP,IL-22R-alpha-2,IL-22RA2,ZCYTOR16
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