Z03017-1
Scientist.com Supplier
IGF-I, Human
GenScript
DESCRIPTION
Insulin-like growth factor I (IGF-I) also known as Somatamedin C is a hormone similar in molecular structure to insulin. Human IGF-I has two isoforms (IGF-IA and IGF-IB) which are differentially expressed by various tissues. Mature human IGF-I shares 94% and 96% aa sequence identity with mouse and rat IGF-I, respectively. Both IGF-I and IGF-II (another ligand of IGF) can signal through the IGF-I receptor (IGFIR), but only IGF-II can bind the IGF-II receptor (IGFIIR/ Mannose-6-phosphate receptor). IGF-I plays an important role in childhood growth and continues to have anabolic effects in adults.
DETAILS
- Form: Lyophilized
- Purity: > 95% as analyzed by SDS-PAGE> 95% as analyzed by HPLC
- Species: Human
- Product Line: Growth Factors
- Expression System: E. coli
- Storage Stability: Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.
- Biological Activity: ED50 < 5.0 ng/ml, measured by a cell proliferation assay using FDC-P1 cells, corresponding to a specific activity of > 2.0 × 105 units/mg.
- Protein Construction: IGF-I (Gly49-Ala118)\nAccession # P05019