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Recombinant Human GDNF



GDNF is a disulfide-linked, homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFRalpha (alpha1-alpha4) receptors. GDNF specifically promotes dopamine uptake and survival, and morphological differentiation of midbrain neurons. Using a Parkinson's disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional human GDNF ligand is a disulfide-linked homodimer consisting of two 15 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, including Cys-101, which is used for inter-chain disulfide bridging, and others that are involved in the intramolecular ring formation known as the cysteine-knot configuration. The calculated molecular weight of Recombinant Human GDNF is 30.4 kDa.


  • Gene Id: 2668
  • Uniprot: P39905
  • Activity: Determined by a cell proliferation assay using SH-SY5Y cells. The expected ED50 for this effect is 1.0-10.0 ng/ml.
  • Category: RUO Cytokines
  • Subcategory: Neurotrophins
  • Research Areas: Angiogenesis/Cardiovascular, Cell Culture, Immune System, Neurobiology, Stem Cells and Differentiation, TGF-beta Superfamily, Organoids
  • Alternative Names: Glial-Derived Neurotrophic Factor, ATF-1
  • Species of Origin: Human
  • Expression System Source: E.coli