Biotinylated Human TNF-alpha Protein, His,Avitag™, active trimer (MALS verified)

DESCRIPTION

Tumor necrosis factor alpha (TNFα) is a cytokine produced primarily by monocytes and macrophages. It is found in synovial cells and macrophages in the tissues.The primary role of TNFα is in the regulation of immune cells. TNFα is able to induce apoptotic cell death, to induce inflammation, and to inhibit tumorigenesis and viral replication. Dysregulation of TNFα production has been implicated in a variety of human diseases, including major depression, Alzheimer's disease and cancer. Recombinant TNFα is used as an immunostimulant under the INN tasonermin. TNFα can be produced ectopically in the setting of malignancy and parallels parathyroid hormone both in causing secondary hypercalcemia and in the cancers with which excessive production is associated.

DETAILS

Tag: C-6×His & C-Avi
Host: HEK293
Size: 200ug
Buffer: PBS, pH7.4
Format: Powder
Purity: 95%
Source: Biotinylated Human TNF-alpha, His,Avitag (TNA-H82E3) is expressed from human 293 cells (HEK293). It contains AA Val 77 - Leu 233 (Accession # NP_000585.2).
Storage: -20℃
Category: MABSol® Biotin Labeled Proteins
Molecule: TNF-alpha
Accession: NP_000585.2
Conjugate: Biotin-labeled
Stability: ● -20°C to -70°C for 12 months in lyophilized state; ● -70°C for 12 months under sterile conditions after reconstitution. For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Exp Region: Val 77 - Leu 233
Swiss-prot: P01375
Package Size: 200ug*1
Characteristics: This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 20.0 kDa. The protein migrates as 21 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE).
Endotoxin Level: 1.0 EU per μg
Molecular Weight: 20.0 kDa
Shipping Condition: RT
Species Reactivity: Human
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