27455
CP 31,398 (hydrochloride)
Cayman Chemical
DESCRIPTION
A p53 stabilizing agent; increases active mutant p53 and p53 reporter gene expression without increasing total protein levels of p53 in H1299 lung cancer cells transfected with mutant p53; is cytotoxic to a panel of 12 human glioma cell lines expressing wild-type or mutant p53 (EC50s = 11.2-22.2 μM); decreases tumor growth in an A375.S2 melanoma mouse xenograft model and completely inhibits tumor growth in a DLD-1 colon cancer mouse xenograft model at 100 mg/kg; dietary administration suppresses lung adenocarcinoma formation in a mouse model of tobacco carcinogen-induced lung adenoma and adenocarcinoma formation at 50 and 100 ppm
DETAILS
- Inchi: InChI=1S/C22H26N4O.2ClH/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17;;/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25);2*1H/b14-11+;;
- Purity: ≥98%
- Raptas: Product Type|Biochemicals||Research Area|Cancer|Cell Signaling|p53 Signaling||Research Area|Cancer|Transcription Factors|p53
- Smiles: CN(C)CCCNC1=NC(/C=C/C2=CC=C(OC)C=C2)=NC3=C1C=CC=C3.Cl.Cl
- Inchikey: WWIFDJIOGCGSBS-IVKCLRODSA-N
- Cas Number: 1217195-61-3
- Formulation: A crystalline solid
- Storage Temp: -20
- Shipping Temp: -20
- Formula Markup: C22H26N4O • 2HCl
- Formula Weight: 435.4
- Shelf Life Days: 1460
Equivalent Items
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