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T25981

Pralatrexate, (S)-

TargetMol

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DETAILS

  • Cas: 1320211-69-5
  • Purity: 98%
  • Smiles: NC=1C2=C(N=CC(C[C@H](CC#C)C3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)N=C(N)N1
  • Category: Compound
  • Molecular Weight: 477.47
  • Molecular Formula: C23H23N7O5

DESCRIPTION

Pralatrexate, (S)- is a folate analog dihydrofolate reductase (DHFR) inhibitor exhibiting high affinity for reduced folate carrier-1 (RFC-1) with antineoplastic and immunosuppressive activities. Pralatrexate selectively enters cells expressing RFC-1; intracellularly, this agent is highly polyglutamylation and competes for the folate binding site of DHFR, blocking tetrahydrofolate synthesis.

Lead Time: 4 - 5 weeks

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