EVP-6124 (hydrochloride)

DESCRIPTION

A partial agonist of α7 subunit-containing nAChRs (IC50 = 22.38 nM); 1,000-fold selective for α7 subunit-containing nAChRs over α4β2 subunit-containing nAChRs at 10 µM, as well as a panel of 60 peptide and nonpeptide receptors, ion channels, and transporters; induces inward currents in Xenopus oocytes expressing human α7 subunit-containing nAChRs (EC50 = 0.16 µM); reverses scopolamine-induced deficits in the novel object recognition task and prevents natural forgetting of a familiar object in rats at 0.1, 0.3, and 1 mg/kg; reduces premature responding in the 5CSRTT in low-attentive female rats

DETAILS

Inchi: InChI=1S/C16H17ClN2OS.ClH/c17-12-3-1-2-11-8-14(21-15(11)12)16(20)18-13-9-19-6-4-10(13)5-7-19;/h1-3,8,10,13H,4-7,9H2,(H,18,20);1H/t13-;/m0./s1
Purity: ≥95%
Raptas: Product Type|Biochemicals|Ion Channel Modulation|Activators||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory
Smiles: ClC1=C2C(C=C(C(N[C@@H]3C4CCN(CC4)C3)=O)S2)=CC=C1.Cl
Inchikey: OIJYTJGIDVTCFF-ZOWNYOTGSA-N
Cas Number: 550999-74-1
Formulation: A crystalline solid
Storage Temp: -20
Shipping Temp: -20
Formula Markup: C16H17ClN2OS • HCl
Formula Weight: 357.3
Shelf Life Days: 1460